For instance, the SERPINA1 gene with genotypes MZ and MS, in this case, represents a protective factor for the development of fibrosis [16], whereas, for example, the polymorphism of the PNPLA3 rs738409 C > G gene is a risk factor for both liver fibrosis and the development of HCC [17]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.