Wang et al. demonstrated that Kisspeptin 1(Kiss1) mRNA levels were significantly higher in the group with endocrine active gonadotroph adenomas than in the nonfunctioning gonadotroph (NFGA) group and correlated with the preoperative serum estradiol levels suggesting a potential role for the Kisspeptin 1 (Kiss1)/Kisspeptin 1 Receptor (Kiss1R), system in the secretion function of FGAs [21]. This evidence concerns the gene KISS1 and functioning gonadotropic adenoma.