In our study, the levels of C-C motif chemokine ligand (CCL)11, interleukin- 6, -7, and (IL)-13, VEGF (vascular endothelial growth factor), plasminogen activator inhibitor-1 (PAI-1), and C-X-C motif chemokine ligand (CXCL)8 were correlated with smoking (orange circle), and smoking pack-years was correlated with periodontitis markers. The gene discussed is SERPINE1; the disease is periodontitis.