In a recent study, a pH-sensitive nanocomposite micelle composed of TfR-T12-PEG-PLGA and TATH7-PEG-PLGA was automatically assembled as a novel drug delivery system for sending chemotherapeutic paclitaxel (PTX) and immunomodulator Toll-7 receptor agonist R837, which successfully delivered PTX and R837 through the BBB and was rapidly ingested by tumor cells and tumor-associated immune cells in an acidic tumor microenvironment with the assistance of transferrin receptor (TfR) [136]. The gene discussed is TFRC; the disease is neoplasm.