One of the most extensive epigenome-wide association studies (EWAS) revealed the CpGs methylation pattern of 52 genes in the blood of European T2DM subjects with the Illumina 450 K methylation array and identified five genes with altered CpG methylation patterns—ABCG1, LOXL2, TXNIP, SLC1A5 and SREBF1—that were significantly associated with the disease [174]. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.