PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Also correlating with NAFLD stages, three genetic forms represented by patatin-like phospholipase domain-containing protein-3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), and sterol regulatory element-binding proteins (SREBP) were found to have a protective effect against CAD [5,95].