In the 773 stages, I–III CRC patients underwent tumor resection surgery [106], and the expression of immune checkpoints at the stromal and tumor levels was evaluated by combining immune checkpoint stromal score (CICSS): CICSS 3 (TIM3- LAG3 and PD1 highly expressed), CICSS 2 (only two markers highly expressed), CICSS 1 (one high marker or weakly expressed markers). Here, LAG3 is linked to neoplasm.