On a background of their efficacy in AML [59,60], phase 1 trials studying the mutant IDH1 inhibitor, ivosidenib, and the mutant IDH2 inhibitor, enasidenib, are both underway in patients with CCUS to determine their impact on hematologic parameters in this population (NCT05030441; NCT05102370). Here, IDH1 is linked to acute myeloid leukemia.