Next, the GScore was evaluated in CCA cell lines and correlated with mutations in HRR-related genes ARID1A, ATM, ATRX, BAP1, BARD1, BLM, BRCA1, BRCA2, BRIP1, CHEK2, CHEK1, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, MRE11, NBN, PALB2, RAD50, RAD51, RAD51B, and RAD51D (Figure 1b, Table S2). This evidence concerns the gene RAD50 and cholangiocarcinoma.