Swierkot et al. [81] evaluated if five SNPs within the TNF-α and TNF receptor encoding genes (TNFA: G−308A, G−238A, C−857T; TNFR1A G36A; and TNFR1B T676G) affect the efficacy of TNF-α inhibitor therapy, including IFX, in 280 patients with RA. The gene discussed is TNF; the disease is rheumatoid arthritis.