In addition, they researched the association between the RTX clinical response and genes coding for cytokines involved in synovitis (IL-10: rs1800896; LTA: rs909253 and rs1041981; TNF-α: rs1800629, rs80267959, and rs1799724; TNFR2: rs1061622) and genes related to RA susceptibility (TRAF1: rs1081848; STAT4: rs7574865; TNFAIP3: rs6920220, and PTPN22L: rs2476601), but no associations were noted. This evidence concerns the gene TNF and rheumatoid arthritis.