BAP1 is a tumor suppressor gene whose loss can drive carcinogenesis in several tissues, and it currently represents one of the most attractive cancer-related genes for several reasons, including its presence in several solid tumors (for example, malignant pleural mesothelioma, basal cell carcinoma, squamous cell carcinoma, uveal melanoma, renal cell carcinoma, etc.), as well as the number of pathways that are indirectly or directly modulated by this gene (e.g., immune cells development, ferroptosis, cell metabolism, etc.)[34]. The gene discussed is BAP1; the disease is basal cell carcinoma.