IGHE and asthma: Other attributes that might be helpful for differentiating asthma from COPD include sex, information from the patient’s family and personal history (family history of asthma, allergen sensitization, history of hay fever, eczema or allergic rhinitis, presence of comorbid diseases such as cardiovascular disease) and biomarkers (eosinophils, IgE, FeNO) [52,53].