TET2 and myelodysplastic syndrome: These studies showed that MDS has a relatively low mutation burden, but there were a number of genes with recurrent mutations, including those involved in DNA methylation (DNMT3A, TET2, IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1), and histone modification (EZH2 and ASXL1) [36,40,41,42,43,44,45,46,47,48].