For instance, in cases of thin basement membrane nephropathy (TBMN), heterozygous mutations in COL4A3/4 are present in 40% [4]; in focal segmental glomerulosclerosis (FSGS), 10% of cases harbor LOF mutations in the mentioned genes [5]; in IgA nephropathy, it has been suggested that individuals with a mutation in the NC1 domain develop antigenic properties against alveolar and glomerular epithelia [6]. This evidence concerns the gene COL4A3 and focal segmental glomerulosclerosis.