In the case of eczema-associated asthma, both HRNR and FLG2 variants alone yielded significantly increased risks; however, the strongest effect was seen in the subjects who combined both at least one HRNR rs877776[C] allele and at least one FLG2 rs12568784 [T] (Table 6). This evidence concerns the gene HRNR and Eczematoid dermatitis.