The distribution analysis of HRNR and FLG2 variants and the combined FLG null genotypes revealed the highest risk for atopic eczema and eczema-associated asthma in subjects who carried compounded risk factors—HRNR risk allele and FLG mutation, combined FGL2 and FLG mutations, or at least one HRNR risk allele together with at least one FLG2 risk allele. This evidence concerns the gene FLG2 and asthma.