FLG2 and asthma: Interestingly, the effects of HRNR rs877776 and FLG2 rs12568784 risk alleles on allergic sensitization were also independent of concomitant allergic diseases, as the associations were significant in the subgroup of controls without eczema and asthma (OR = 9.04; 95%CI 2.28 ÷ −35.76; p = 0.002).