The case–control study design enabled us to evaluate the association between HRNR and FLG2 SNPs and asthma in the overall population because all cases of physician diagnoses of asthma by the age of 6 were observed in patients with atopic eczema; therefore, all our patients with asthma represented the complex phenotype—asthma plus eczema. This evidence concerns the gene FLG2 and asthma.