Interestingly, the combination of any tested risk variants, HRNR rs877776[C] or FLG2 rs12568784[T] with FLG mutations, provided the best combination of diagnostic specificity (100%) and predicted eczema plus the asthma phenotype with a positive predictive value of 100% (Table 7). This evidence concerns the gene FLG2 and Eczematoid dermatitis.