In our population, HRNR rs877776[C] or FLG2 rs12568784[T] alone were modestly strong predictors with positive predictive values of 45.7% and 53.6%, respectively; this indicates that nearly half of the eczema cases who carried the HRNR or FLG2 risk variants will develop eczema-associated asthma phenotype. Here, FLG2 is linked to asthma.