The combined analysis for FLG2 and FLG variants demonstrated that, compared to the reference group carrying neither genetic risk factor, the strong effect was revealed only in subjects who carried both risk factors; the presence of at least one FLG2 rs12568784 [T] allele and at least one loss-of-function FLG mutation significantly increased the atopic eczema risk. This evidence concerns the gene FLG2 and atopic eczema.