Many initial risk factors influencing the outcomes of SLE and LN have been described and highlighted: non-modifiable risk factors such as sex [30,31,32], age at LN onset [3,33], early LN [34], and LN recurrence, clinical and biological parameters such as hypertension [35], elevated initial serum creatinine [5,33,36,37,38], elevated initial proteinuria [33,36,39], pathological information [33,40], chronicity index [41,42,43], and ISN/RPS class [44,45], and genetic factors such as Apol1 [46]. The gene discussed is APOL1; the disease is hypertensive disorder.