Cited2−/− mice die during gestation with diverse cardiovascular malformations, such as atrial and ventricular septal defects (ASD/VSD), aberrant aortic arches, and common arterial trunk and left–right patterning defects [31,42], a phenotype very similar to that of patients with heterozygous de novo variants in MYRF. Here, MYRF is linked to atrial septal defect.