Despite the fact that the cellular and tissue-specific pathways during pregnancy-induced hypertension are becoming more and more known, including vascular endothelial growth factor A (VEGF-A), mRNAs encoding VEGF-C, placental growth factor (PlGF), the angiopoietins angiopoietin 1 (Ang1) and Ang2, and the receptors VEGFR-3 (Flt-4), Tie 1 and Tie 2 [12,13], the exact etiology remains unclear. This evidence concerns the gene FLT4 and hypertensive disorder.