IPL treatment with a vascular filter could potentially be a replacement treatment modality in young patients and in those with a toothpaste-like meibum consistency in moderate to severe MGD, as evidenced by the findings that IPL with a vascular filter can safely and effectively relieve MGD signs and symptoms, especially the lid margin telangiectasia and ocular surface MMP-9 expression. The gene discussed is MMP9; the disease is Telangiectasia.