MAPK8 and coronary artery disorder: Similarly, other studies highlighted the role of the macrophages in EAT inflammation, as Baker et al. stated in their study that in CAD patients, there is an increase in the expression of the nuclear factor kappaB (NF-kB) and c-Jun N-terminal kinase (JNK), compared to patients without CAD; also between CD-68 and toll-like receptor-2 and toll-like receptor-4 and TNF-α, a strong correlation has been demonstrated [36].