MMP1 and renal fibrosis: Vit-E has also been reported to diminish the expression of genes involved in fibrotic process, such as matrix metalloproteinase-1 (MMP-1), IL-1β, or collagen [44,45,46], and delay the progression of liver fibrosis, radiation-induced fibrosis, and renal fibrosis [47,48,49,50,51].