In summary, our study showed that the fluctuation in serum LH level in GnRH-antagonist protocol could interfere with pregnancy outcomes in PCOS women receiving IVF/ICSI treatment and the ratio of hLH/bLH could be a more sensitive indicator for evaluating the LH level on the embryo development potential in women with PCOS in a GnRH-antagonist protocol. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.