CRP and obesity due to melanocortin 4 receptor deficiency: This might be a “paradoxical” statistical artifact (due to the six out of 72 subjects falling in this group), but, in our opinion, because of the association of epigenetic loci in its gene with inflammation and CVD [37], CRP might become the “perpetrator and victim” of the same obesity-related DNA destabilization previously described [38,39,40,41,42].