Finally, the increased activation of the hemostatic system, manifested by elevated levels of markers of thrombosis, such as D-dimers, von Willebrand factor, and prothrombin fragments, suggests that, in addition to hypercellularity, abnormalities in the coagulation pathway contribute to the prothrombotic state in MPNs, including ET patients [32]. The gene discussed is F2; the disease is essential thrombocythemia.