ABL1 and myeloproliferative disorder: Increased platelet production is observed during severe inflammation, as the inflammatory environment promotes the formation of MKs in essential thrombocythemia: one of the chronic, BCR-ABL-negative, myeloproliferative neoplasms (MPN), characterized by an increased number of mature MKs and a sustained platelet count of above 450 × 109 platelets/L [4].