Some trials have studied the effect of insulin in HF: the ORIGIN trial (Outcome Reduction with Initial Glargine Intervention) [95] and the DEVOTE trial (A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects with Type 2 Diabetes at High Risk of Cardiovascular Events) [96]. This evidence concerns the gene INS and type 2 diabetes mellitus.