Moreover, in adult patients with AD, disease severity has been associated with Staphylococcus aureus skin colonization, resulting in more severe disease, barrier disruption, elevation of levels of type 2 biomarkers (eosinophil count, TARC/CCL17, IgE, periostin) and LDH, and greater allergen sensitization [51]. The gene discussed is IGHE; the disease is Alzheimer disease.