RNASE3 and Alzheimer disease: Other biomarkers for AD severity include markers correlated with general inflammation or allergy such as C-reactive protein (CRP) [39], serum lactate dehydrogenase (LDH) [39,40,41], peripheral eosinophil count and serum eosinophil cationic protein (ECP), a protein released during the degranulation of eosinophils [13,40,41,42,43,44].