In Mucor circinelloides (a cause of mucormycosis), the RNAi-based epigenetic drug-resistance mechanism, epimutation, has been shown to confer resistance to FKBP12 (peptidyl-prolyl isomerase)-binding antifungal agents, FK506 and rapamycin, which block calcineurin and TOR signaling pathways, respectively [30], the fkbA gene codes for the FKBP12 protein. This evidence concerns the gene FKBP1A and Zygomycosis.