The mechanisms associated with NaB-induced apoptosis were explored in a different study that assessed anticancer activity against the MRK-nu-1 breast cancer cell line and a significant time-dependent increase in caspase-10 mRNA expression following treatment with NaB in comparison to levels of caspase-3 or caspase-8 was observed [25]. The gene discussed is CASP10; the disease is breast carcinoma.