We contoured three subtypes: epithelial (diffuse membrane expression of E-cadherin and β-catenin associated with negative vimentin), mesenchymal (loss of E-cadherin expression, positive vimentin and nuclear staining of β-catenin and maspin) and one with mixed epithelial-mesenchymal features called hybrid (epithelial-like pattern in the tumor center and mesenchymal characteristics in the invasion front), all of them exemplified in Figure 2 [51,56]. The gene discussed is CDH1; the disease is neoplasm.