The TrkB.full/Trk.T1 ratio has been shown to be connected to stress-induced cognitive decline [41], and in schizophrenia patients, this ratio has a predictive value as a lower ratio in the periphery (lower expression of the full receptor and higher truncated expression) was associated with worse clinical response to an antipsychotic [50]. This evidence concerns the gene NTRK2 and schizophrenia.