NTRK2 and Alzheimer disease: One-way ANOVA and Tukey’s multiple comparisons test on the expression of TrkB-trunked receptor (TrkB.T1) found that the AD mice had more TrkB.T1 expression than WT mice (p = 0.002), while there was no such upregulation in the treated AD mice of both age groups (6 months old: F (1, 31) = 30.87, p < 0.001, Figure 2A).