The serological markers of APS include IgG and/or IgM antibodies to cardiolipin (aCL) in serum or plasma, which are present in medium or high levels (>40 GPL or MPL units), IgG and/or IgM antibodies to beta-2 glycoprotein 1 (anti-β2-GP1), and lupus anticoagulant (LA), which are detected two or more times at a study time interval of at least 12 weeks [3]. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.