Regarding patients with TLR4 SNPs, the most common causes of death were sepsis, hepatic coma and variceal bleeding (each with two patients); in patients with wild-type TLR4, hepatic coma with 16 patients and sepsis with six patients were the most common causes of death; no statistically significant differences were found between patients with and without TLR4 SNPs (Supplementary Table S1). This evidence concerns the gene TLR4 and Sepsis.