TLR4 and hepatocellular carcinoma: In a multivariable model involving TLR4 mutations, age, gender, MELD and CTP scores and cause of cirrhosis, TLR4 mutations showed a statistically significant correlation with overall survival (hazard ratio (HR): 0.327, p value 0.0271), and similarly MELD (HR: 0.911, p value 0.0264) and CTP (HR: 1.422, p value 0.0200); on the contrary, no other factor proved to have a role in HCC patient survival.