In a multivariable approach involving TLR4 mutations, MELD, CTP, patients’ age, gender and cause of cirrhosis, gender proved to be a statistically significant factor (p = 0.0123) with a HR for females to males of 0.28, as well as MELD (HR: 0.92, p = 0.0313) and CTP scores (HR: 1.40, p = 0.0140). The gene discussed is TLR4; the disease is Cirrhosis.