CNR1 and metabolic dysfunction-associated steatohepatitis: Interestingly, in the human liver cell line HepG2, the activation of CB2R significantly modulated lipogenesis and induced the increased expression of CB1R, indicating that, beyond its direct contribution in the setting of NAFLD and NASH, the activation of hepatic CB2R would also potentiate the deleterious effects of hepatic CB1R, thus creating a vicious cycle [49].