NLRP3 and metabolic dysfunction-associated steatohepatitis: Conversely, similar to what was observed in a mouse model of NASH [62], Jiang et al. showed that the feeding of mice with excessive alcohol promoted caspase-1-induced pyroptosis in Kupffer cells, with the activation of the NLRP3 inflammasome and the release of a high amount of proinflammatory cytokines, which thus exacerbated the liver inflammation [34].