APOB and atherosclerosis: Recently, a prospective cohort analysis of data from the UK Biobank and from two large clinical trials, Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) and IMPROVE-IT, was undertaken to examine whether the cholesterol content or the TG content of lipoproteins is associated with ASCVD risk beyond the number of apoB-containing lipoproteins [79].