APOA1 and coronary artery disorder: A de novo genome-wide association study was conducted to examine lipid-related traits (apoB, LDL-C, TG, HDL-C, and apoA1) associated with risk of CHD using data from the UK Biobank (~440,000 participants) followed by Mendelian randomization analysis using data from the CARDIoGRAMplusC4D consortium with over 60,000 cases of CHD [77].