Furthermore, the external validation analysis showed that a genetic score that consisted of variants associated with discordant changes between LDL-C and apoB concentration, similar to that seen when CETP variants are combined with HMGCR variants, was associated with a similar risk of CHD per unit change in apoB, but an attenuated risk of CHD per unit change in LDL-C. This evidence concerns the gene CETP and coronary artery disorder.