CETP inhibition with dalcetrapib was also shown to reduce atherosclerosis, increase HDL-C, and reduce non-HDL-C in normolipidemic rabbits [34,35], but when administered to cholesterol-fed rabbits with severe hypercholesterolemia, it did not reduce atherosclerosis, despite significantly increasing HDL-C [36]. The gene discussed is CETP; the disease is atherosclerosis.