APOB and atherosclerosis: The causality of LDL-C and VLDL-C with increased ASCVD risk is supported by a large body of evidence from observational investigations, RCTs, and Mendelian randomization studies, but the relationship loses significance when apoB is accounted for, supporting the view that it is the number of circulating apoB-containing lipoprotein particles that drives risk [21,22,23,24,25].