Furthermore, the interventions in REVEAL and in the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) (anacetrapib and ezetimibe, respectively) reduced apoB by approximately the same amount, and this translated into similar reductions in risk of MACE (defined as the composite of cardiovascular death, myocardial infarction, ischemic stroke, or coronary revascularization) (Table 2) [18,46]. Here, APOB is linked to myocardial infarction.