The Copenhagen City Heart Study, which followed more than 10,000 participants for up to 34 years, found that two common CETP gene polymorphisms which reduce CETP activity were associated with significant reductions in the risks for any ischemic vascular event (hazard ratio [HR] 0.76; 95% confidence interval [CI] 0.68–0.85), ischemic heart disease, myocardial infarction, ischemic cerebrovascular disease, ischemic stroke, and total mortality, as well as an antiatherogenic lipid profile (increased HDL-C and decreased LDL-C, non-HDL-C, and TG) [38]. Here, CETP is linked to ischemic stroke.