Among nearly 400,000 primary prevention individuals and over 40,000 patients with established ASCVD, apoB, non-HDL-C, and TG were each individually shown to be associated with incident myocardial infarction, but, when assessed together, only apoB was significantly associated with increased risk (HR per 1 standard deviation 1.27; 95% CI 1.15–1.40; p < 0.001 for the primary prevention analysis). The gene discussed is APOB; the disease is myocardial infarction.