Conversely, metabolites such as 3-hydroxy-isobutyrric acid, retinoic acid, 2-keto-isocaproic acid, suberic acid, and ethyl-malonic acid results were specifically altered when the BBS_CKD was compared to CTR_CKD, highlighting the key role of BBS in the progressive onset of chronic kidney disease (Figure 2a). The gene discussed is BBS2; the disease is chronic kidney disease.