TGFB1 and diabetes mellitus: Additionally, Hus et al. found that miR-29a regulates the DKK1/Wnt/β-catenin signaling pathway and TGF-β1-mediated renal tissue fibrosis, in addition to maintaining Wnt/β-catenin signaling activity to prevent diabetes-induced extracellular matrix accumulation and renal injury [39].