Common PET radiomics procedures for response evaluation of NSCLC have been employing volume and metabolism of the tumor and sometimes the muscle, using quantitative indices such as SUV, which are combined with PD-L1 immunohistochemical staining and driver mutations of the tumor, patient characteristics such as smoking history, age, sex, ECOG Performance Status, and blood examination to generate a feature map as a test set for further validation. Here, CD274 is linked to neoplasm.