We found that compared with HC, the PBMCs of aMCI patients showed an increase in several senescence markers, such as SA-β-Gal and G0/G1, as well as IL-6 and IL-8 mRNA expression and IL-8 plasmatic levels, suggesting that some markers of senescence might be increased as a peripheral manifestation at early stages of the neurodegenerative disease. Here, IL6 is linked to neurodegenerative disease.