In another study, treatment with the selective HDAC6i, Ricolinostat or Citarinostat, still resulted in dose-dependent inhibition of cell survival in CRISPR-induced HDAC6 knock-out melanoma (A375 cells), colorectal (DLD1 cells), triple negative breast cancer (MDA-MB-231) and ovarian (TOV-21G cells) cell lines [107]. The gene discussed is HDAC6; the disease is melanoma.