Histologically, AD is characterized by the pathologic accumulation of extracellular amyloid beta (Aβ) and abnormally hyperphosphorylated intracellular tau filaments in neurons, leading to senile plaques and neurofibrillary tangles, respectively, with neuropathological lesions preceding clinical signs by many years [3,4,5]. Here, MAPT is linked to Alzheimer disease.