NDRG2 is considered a PTEN-binding protein recruiting protein phosphatase 2A (PP2A) to PTEN, which inhibits PI3K-AKT pathway via PTEN activation by PP2A in adult T-cell leukemia-lymphoma (ATLL) (Figure 1) [67]. The gene discussed is PTEN; the disease is adult T-cell leukemia/lymphoma.