A literature review of miRNAs involved in individual organs (brain, heart, lung, liver, kidney, and blood) during sepsis revealed that the most frequently mentioned target genes and pro-target AKTs (serine/threonine kinases), FOXs (forkhead box), and HMGs (high-mobility groups) are NF-κB (nuclear factor kappa B), SIRT (sirtuin), SOCS (suppressor of cytokine signaling), STAT (signal transducer and activator of transcription), TRAF (TNF receptor-associated factor), and most importantly, PTEN (phosphatase and tensin homolog). This evidence concerns the gene MARK2 and Sepsis.