Likewise, SEPT4, which has been found in neurofibrillary tangles and in α-synuclein-positive cytoplasmic inclusions (Lewy bodies) in PD brains, is phosphorylated by DYRK1A (Table 1) which leads to more α-synuclein (α-syn) aggregation and loss of dopaminergic neurons [77]. The gene discussed is DYRK1A; the disease is Parkinson disease.