PSEN1 and Alzheimer disease: It was shown that DYRK1A overexpression might also phosphorylate PS1, 9G8, SC35 and, SRp55 (at Ser280, Ser303, and Ser316) promoting tau exon 10 inclusion and leading to an increase in 3R-tau expression, which may initiate or accelerate tau pathology in AD patients’ brains [11,32,39,43,70,74,78,82,101].