Several studies have employed T2DM-like diabetic models developed through a combined treatment of STZ with a high-fat diet (HFD), reporting elevated blood insulin levels and a further reduction of pancreatic β-cell function [21,22,23,24]; nevertheless, the mechanisms underlying DPN have not been fully explored, particularly the clinical implications of SEPT9′s role in T2DM. This evidence concerns the gene INS and type 2 diabetes mellitus.