Indeed, NOD2−/− recipients of lamina propria mononuclear cells (LPMC) from ethanol-treated NOD2−/− donors that had been depleted of CD4+LAP+Foxp3− cells exhibited increased TNBS-induced weight loss when compared to NOD2−/− recipients of intact LPMCs, which did not develop colitis [42]. This evidence concerns the gene CD4 and colitis.