Although colitis in this model was accredited to the production of the Th1 cytokine IFN-γ [9,140], enhanced emergence of IL-17A+IFN-γ population of T cells and suppression of populations of Foxp3+ and IL-10-producing regulatory T cells was attributed to IL-23R signalling in T cells [141]. The gene discussed is FOXP3; the disease is colitis.