Recently, inhibition of CypA was shown to significantly suppress the proliferation of gastric cancer cells by downregulating the CD147-mediated phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR), c-Jun N-terminal kinase (JNK), and ERK1/2 pathways [13,54,60,61]. Here, MAPK8 is linked to gastric cancer.