Moreover, CypA and CD147 were overexpressed in mycosis fungoides/Sézary syndrome (MF/SS) tumor cells, and inhibition of CypA and CD147 suppressed the proliferation of cutaneous T-cell lymphoma cell lines both in vitro and in vivo by downregulating the phosphorylation of ERK1/2 and protein kinase B (AKT) [59]. This evidence concerns the gene AKT1 and primary cutaneous T-cell non-Hodgkin lymphoma.