Studies with a murine ALS model have found modified mitochondrial structures and nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation, which generally occurs due to OS-induced damage and stimulates the formation of intracellular antioxidant molecules, during early ALS stages, implying OS involvement in the initial phase of ALS [19,20]. This evidence concerns the gene NFE2L2 and amyotrophic lateral sclerosis.