They introduced Card14ΔE138K/A mutations in mice with psoriasis and found an up-regulation of pro-inflammatory cytokines, IL-23, IL-19, IL-22 and IL-17; chemokines Cxcl1, Ccl20, and Cxcl2; and antimicrobial peptides, Lcn2 and Defb4. This evidence concerns the gene IL22 and psoriasis.