In vitro and in vivo neuroprotection against 6-OHDA toxicity in DA neurons, and preserved motor functions involving the dopamine system in mouse (PD). PRX2 exhibited antioxidant and anti-apoptotic effects via suppression of apoptosis signal-regulating kinase (ASK1)-dependent activation of the c-Jun N-terminal kinase/c-Jun and p38 pro-death pathways. This evidence concerns the gene JUN and Parkinson disease.