PRPF31 is involved in the regulation of the metformin response to type 2 diabetes [18], which suggests that PRPF31 has a potential glucose metabolism function, but there is no evidence that it affects cancer development; in contrast, ISYNA1 is responsible for inositol synthesis [19], but its effect on glucose metabolism is more indirect. Here, ISYNA1 is linked to type 2 diabetes mellitus.